Neuropathological analysis of lacunes and microvascular lesions in late-onset depression
نویسندگان
چکیده
منابع مشابه
Neuropathological analysis of lacunes and microvascular lesions in late-onset depression.
AIMS Previous neuropathological studies documented that small vascular and microvascular pathology is associated with cognitive decline. More recently, we showed that thalamic and basal ganglia lacunes are associated with post-stroke depression and may affect emotional regulation. The present study examines whether this is also the case for late-onset depression. METHODS We performed a detail...
متن کاملDifferential impact of lacunes and microvascular lesions on poststroke depression.
BACKGROUND AND PURPOSE Previous studies have postulated that poststroke depression (PSD) might be related to cumulative vascular brain pathology rather than to the location and severity of a single macroinfarct. We performed a detailed analysis of all types of microvascular lesions and lacunes in 41 prospectively documented and consecutively autopsied stroke cases. METHODS Only cases with fir...
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15 صفحه اولNeuropathological correlates of late-life depression in older people.
BACKGROUND Depression is common in old age and is associated with risk of dementia, but its neuropathological correlates in the community are unknown. AIMS To investigate for the first time in a population-representative sample of people with no dementia the association between depression observed during life and neurofibrillary tangles, diffuse and neuritic plaques, Lewy bodies, brain atroph...
متن کاملA neuropathological study of vascular factors in late-life depression.
OBJECTIVES Depression is a common psychiatric disorder in late life and it may be associated with vascular disease processes. Although there are clinical and neuroimaging studies lending support to such a "vascular depression" hypothesis there have been no neuropathological studies to directly test this. Postmortem tissue was investigated to determine whether late life depression was associated...
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ژورنال
عنوان ژورنال: Neuropathology and Applied Neurobiology
سال: 2010
ISSN: 0305-1846
DOI: 10.1111/j.1365-2990.2010.01101.x